Vybion Drug Pipeline

Key Takeaways

INT41 reduces DNA binding of N-terminal Htt (Q73) to normal (Q23) levels

Gene dysregulation decreases due to reduced DNA binding by N-terminal fragments.

01

Prevents aggregate formation in vitro and in vivo

Accelerates Htt degradation.

02

Decreases gene dysregulation by 50% in vitro

No off-target effects observed (RNA arrays).

03

INT41 does not interact with full-length Htt

04

INT41 may stabilize or alter fragment structure, impacting turnover

05